Jena Bioscience抗病毒核苷/核苷酸類似物--助力新型冠狀病毒藥物研發(fā)

    持續(xù)近兩個多月的新型冠狀病毒感染的肺炎疫情牽動著每一個人的心，為了打贏這場疫情防控狙擊戰(zhàn)，搞清致病機理，研發(fā)抗病毒藥物和疫苗刻不容緩。Jena bioscience品牌有豐富的抗病毒核苷酸/核苷酸類似物，助力抗病毒藥物研發(fā)。


抗病毒核苷及核苷酸類似物主要有:

抗病毒核苷/核苷酸類似物可以通過抑制病毒復(fù)制的幾個關(guān)鍵過程來抑制病毒繁殖，它們通過與天然的dNTP/NTP競爭結(jié)合到新的病毒核酸中，從而導(dǎo)致鏈終止或者誘變。在細胞培養(yǎng)實驗中，可以用抗病毒核苷酸的非磷酸化核苷變體，這種核苷酸在細胞內(nèi)被多種病毒和/或宿主激酶激活，從而發(fā)揮(tri)磷酸化形式的抗病毒作用。

 


熱銷抗病毒核苷/核苷酸類似物：

品牌

貨號

品名

規(guī)格

Jena Bioscience

NU-1605S

3TCMP

10 μl (10 mM)

Jena Bioscience

NU-1605L

3TCMP

5 x 10 μl (10 mM)

Jena Bioscience

NU-1606S

3TCTP

5 μl (10 mM)

Jena Bioscience

NU-1606L

3TCTP

5 x 5 μl (10 mM)

Jena Bioscience

NU-1603S

d4TMP

20 μl (10 mM)

Jena Bioscience

NU-1603L

d4TMP

5 x 20 μl (10 mM)

Jena Bioscience

NU-1601S

AzTMP

20 μl (10 mM)

Jena Bioscience

NU-1601L

AzTMP

5 x 20 μl (10 mM)

Jena Bioscience

NU-989S

AzTTP

10 μl (100 mM)

Jena Bioscience

NU-989L

AzTTP

5 x 10 μl (100 mM)

Jena Bioscience

NU-875             

ara-Adenosine-5'-monophosphate (ara-AMP)

2 mg

Jena Bioscience

NU-1111S

ara-Adenosine-5'-triphosphate (ara-ATP)

50 μl (10 mM)

Jena Bioscience

NU-1111L

ara-Adenosine-5'-triphosphate (ara-ATP)

5 x 50 μl (10 mM)

Jena Bioscience

NU-876

Acyclovir-5'-monophosphate

2 mg

Jena Bioscience

NU-877

Acyclovir-5'-triphosphate

2 mg

Jena Bioscience

NU-021-2

Ribavirin-5'-monophosphate

2 mg

Jena Bioscience

NU-1105S

Ribavirin-triphosphate

20 μl (10 mM)

Jena Bioscience

NU-1105L

Ribavirin-triphosphate

5 x 20 μl (10 mM)

Jena Bioscience

N-DN-8234-100

β-L-2'-Deoxythymidine

100 mg

Jena Bioscience

NU-896S

6-Aza-UTP

10 μl (100 mM)

Jena Bioscience

NU-896L

6-Aza-UTP

5 x 10 μl (100 mM)

Jena Bioscience

NU-974

Tenofovir

100 mg

Jena Bioscience

NU-975

Tenofovir-diphosphate

1 mg

Jena Bioscience

NU-989S

AzTTP

10 μl (100 mM)

Jena Bioscience

NU-989L

AzTTP

5 x 10 μl (100 mM)

Jena Bioscience

NU-275S

Ganciclovir-triphosphate

10 μl

Jena Bioscience

NU-275L

Ganciclovir-triphosphate

5 x 10 μl

 



西美杰是Jena bioscience中國總代理，為用戶提供完善的技術(shù)與售后服務(wù)。如對產(chǎn)品感興趣歡迎撥打西美杰客服熱線400-050-4006了解詳細信息。西美杰會更好的協(xié)助科研工作者的實驗工作，支持全國戰(zhàn)“疫”，早日戰(zhàn)勝病毒。武漢加油！中國加油！


參考文獻：

1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18. 
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740. 
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154. 
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34. 
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375. 
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press. 
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.

 

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